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이매스교육 및 공지사항
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[LC/MS] Contaminants of LC/MS -
작성자
이매스 -
첨부파일
No sample (Blank run, LC buffer run) 에서 여러가지 background peaks 가 높게 나오고 있다면 고려해 볼만한 원인입니다.
■ Polyethylene Glycol (PEG) or PEG-Like Materials
■ Description
- Polymer series
■ Sources of PEG
- Organic solvents
- MS calibration solutions
- Hand cream
- Sample detergents
- Glassware (dishwashing detergents)
- Cleaning solutions from manufacturing
- MS calibration solutions
- Hand cream
- Sample detergents
- Glassware (dishwashing detergents)
- Cleaning solutions from manufacturing
■ Metal ions
■ Sodium and Potassium
■ Iron
■ Iron
- Sources
o Water and acetonitrile
o Acetic acid (lower in formic acid)
o Non-passivated stainless steel parts
o Water and acetonitrile
o Acetic acid (lower in formic acid)
o Non-passivated stainless steel parts
■ Nickel
- Source
o Hastelloy C-276 metal used in solvent filters
- Source
o Hastelloy C-276 metal used in solvent filters
■ Molybdenum
- Molybdenum adducts of ACN + FA + H2O
- m/z = 240
- Sources
o Hastelloy C-276 metal used in solvent filters
- m/z = 240
- Sources
o Hastelloy C-276 metal used in solvent filters
■ Phthalates
■ Plasticizer
■ Common phthalates include:
o Di-2-ethylhexyl phthalate (DEHP) [M+H] = 391
o Diisodecyl phthalate (DIDP) [M+H] = 447
o Diisononyl phthalate (DINP) [M+H] = 419
o Diisooctyl phthalate (DIOP) [M+H] = 391
o Di-2-ethylhexyl phthalate (DEHP) [M+H] = 391
o Diisodecyl phthalate (DIDP) [M+H] = 447
o Diisononyl phthalate (DINP) [M+H] = 419
o Diisooctyl phthalate (DIOP) [M+H] = 391
■ Adducts formed for Diisooctyl phthalate (DIOP)
o [M+Na]+ = 413
o [M+K]+ = 429
o [2M+NH4]+ = 798
o [2M+Na]+ = 803
- Phthalic anhydride m/z =149 prevalent fragment observed
o [M+Na]+ = 413
o [M+K]+ = 429
o [2M+NH4]+ = 798
o [2M+Na]+ = 803
- Phthalic anhydride m/z =149 prevalent fragment observed
■ Sources
o Water and organic solvents that have come in contact with plastics
o Extracted from plastic tubing, water storage containers, vials, caps
o Laboratory air
o Water and organic solvents that have come in contact with plastics
o Extracted from plastic tubing, water storage containers, vials, caps
o Laboratory air
■ Siloxanes
■ Siloxanes are
often present in laboratory air. These compounds, which exist in deodorant and other cosmetic products.
often present in laboratory air. These compounds, which exist in deodorant and other cosmetic products.
■ Airborne phthalates
■ Polysiloxane [O-Si(CH3)2-]n
C-18 column bleed & common air contaminant.
May also come from spray chamber vent.
- [M+H] : 371, 445, 519, 593, 667, 741
C-18 column bleed & common air contaminant.
May also come from spray chamber vent.
- [M+H] : 371, 445, 519, 593, 667, 741